SrasV1, Main, Exploration, bibRecord, 003C80

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase.

Identifieur interne : 003C80 ( Main/Exploration ); précédent : 003C79; suivant : 003C81

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase.

Auteurs : Yi-Ru Gan [République populaire de Chine] ; He Huang ; Yong-Dong Huang ; Chun-Ming Rao ; Yang Zhao ; Jin-Sheng Liu ; Lei Wu ; Dong-Qing Wei

Source :

Peptides [ 0196-9781 ] ; 2006.

RBID : pubmed:16242214

Descripteurs français

KwdFr :
- Animaux, Antienzymes (), Antienzymes (pharmacologie), Antienzymes (synthèse chimique), Antiviraux (), Antiviraux (métabolisme), Cellules Vero, Cysteine endopeptidases (métabolisme), Données de séquences moléculaires, Oligopeptides (), Oligopeptides (pharmacologie), Oligopeptides (synthèse chimique), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), Séquence d'acides aminés, Virus du SRAS (), Virus du SRAS (enzymologie).
MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- métabolisme : Antiviraux, Cysteine endopeptidases, Protéines virales.
- pharmacologie : Antienzymes, Oligopeptides.
- synthèse chimique : Antienzymes, Oligopeptides.
- Animaux, Antienzymes, Antiviraux, Cellules Vero, Données de séquences moléculaires, Oligopeptides, Séquence d'acides aminés, Virus du SRAS.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Antiviral Agents (chemistry), Antiviral Agents (metabolism), Chlorocebus aethiops, Cysteine Endopeptidases (metabolism), Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), Molecular Sequence Data, Oligopeptides (chemical synthesis), Oligopeptides (chemistry), Oligopeptides (pharmacology), SARS Virus (drug effects), SARS Virus (enzymology), Vero Cells, Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Enzyme Inhibitors, Oligopeptides.
- chemical , chemistry : Antiviral Agents, Enzyme Inhibitors, Oligopeptides.
- chemical , metabolism : Antiviral Agents, Cysteine Endopeptidases, Viral Proteins.
- chemical , pharmacology : Enzyme Inhibitors, Oligopeptides.
- drug effects : SARS Virus.
- enzymology : SARS Virus.
- Amino Acid Sequence, Animals, Chlorocebus aethiops, Molecular Sequence Data, Vero Cells.

Abstract

The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV Mpro with the octapeptide AVLQSGFR reported recently as well as the "Chou's distorted key" theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration.

DOI: 10.1016/j.peptides.2005.09.006
PubMed: 16242214

Affiliations:

Le document en format XML

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<author><name sortKey="Gan, Yi Ru" sort="Gan, Yi Ru" uniqKey="Gan Y" first="Yi-Ru" last="Gan">Yi-Ru Gan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China. lifescience@san.rr.com</nlm:affiliation>
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<author><name sortKey="Huang, He" sort="Huang, He" uniqKey="Huang H" first="He" last="Huang">He Huang</name>
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<author><name sortKey="Huang, Yong Dong" sort="Huang, Yong Dong" uniqKey="Huang Y" first="Yong-Dong" last="Huang">Yong-Dong Huang</name>
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<author><name sortKey="Rao, Chun Ming" sort="Rao, Chun Ming" uniqKey="Rao C" first="Chun-Ming" last="Rao">Chun-Ming Rao</name>
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<author><name sortKey="Zhao, Yang" sort="Zhao, Yang" uniqKey="Zhao Y" first="Yang" last="Zhao">Yang Zhao</name>
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<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (metabolism)</term>
<term>Chlorocebus aethiops</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Enzyme Inhibitors (chemical synthesis)</term>
<term>Enzyme Inhibitors (chemistry)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Molecular Sequence Data</term>
<term>Oligopeptides (chemical synthesis)</term>
<term>Oligopeptides (chemistry)</term>
<term>Oligopeptides (pharmacology)</term>
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<term>Oligopeptides (synthèse chimique)</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Protéines virales (métabolisme)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (enzymologie)</term>
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<front><div type="abstract" xml:lang="en">The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV Mpro with the octapeptide AVLQSGFR reported recently as well as the "Chou's distorted key" theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration.</div>
</front>
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<name sortKey="Liu, Jin Sheng" sort="Liu, Jin Sheng" uniqKey="Liu J" first="Jin-Sheng" last="Liu">Jin-Sheng Liu</name>
<name sortKey="Rao, Chun Ming" sort="Rao, Chun Ming" uniqKey="Rao C" first="Chun-Ming" last="Rao">Chun-Ming Rao</name>
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Serveur d'exploration SRAS

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase.

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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